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Pro Anabolic - Strongest Legal Testosterone Booster Without Steroids or HGH

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Baalmann, Joe (2017-06-19). "Testosterone can be part of your treatment plan for Raynaud's Disease". BioBalance Health . Retrieved 2023-06-09. In low doses as a component of hormone therapy for postmenopausal and transgender women, for instance to increase energy, well-being, libido, and quality of life, as well as to reduce hot flashes. [43] [44] [45] [46] Testosterone is usually used for this purpose, although methyltestosterone is also used. [46] [47] Changes in endogenous testosterone levels may also contribute to differences in myotrophic–androgenic ratio between testosterone and synthetic AAS. [67] AR agonists are antigonadotropic – that is, they dose-dependently suppress gonadal testosterone production and hence reduce systemic testosterone concentrations. [67] By suppressing endogenous testosterone levels and effectively replacing AR signaling in the body with that of the exogenous AAS, the myotrophic–androgenic ratio of a given AAS may be further, dose-dependently increased, and this hence may be an additional factor contributing to the differences in myotrophic–androgenic ratio among different AAS. [67] In addition, some AAS, such as 19-nortestosterone derivatives like nandrolone, are also potent progestogens, and activation of the progesterone receptor (PR) is antigonadotropic similarly to activation of the AR. [67] The combination of sufficient AR and PR activation can suppress circulating testosterone levels into the castrate range in men (i.e., complete suppression of gonadal testosterone production and circulating testosterone levels decreased by about 95%). [48] [158] As such, combined progestogenic activity may serve to further increase the myotrophic–androgenic ratio for a given AAS. [67] GABA A receptor modulation [ edit ] The traditional routes of administration do not have differential effects on the efficacy of the drug. Studies indicate that the anabolic properties of AAS are relatively similar despite the differences in pharmacokinetic principles such as first-pass metabolism. However, the orally available forms of AAS may cause liver damage in high doses. [8] [75] Adverse effects [ edit ]

Performance-enhancing drugs: Know the risks - Mayo Clinic Performance-enhancing drugs: Know the risks - Mayo Clinic

Endogenous/natural AAS like testosterone and DHT and synthetic AAS mediate their effects by binding to and activating the AR. [72] On the basis of animal bioassays, the effects of these agents have been divided into two partially dissociable types: anabolic (myotrophic) and androgenic. [72] Dissociation between the ratios of these two types of effects relative to the ratio observed with testosterone is observed in rat bioassays with various AAS. [72] Theories for the dissociation include differences between AAS in terms of their intracellular metabolism, functional selectivity (differential recruitment of coactivators), and non-genomic mechanisms (i.e., signaling through non-AR membrane androgen receptors, or mARs). [72] Support for the latter two theories is limited and more hypothetical, but there is a good deal of support for the intracellular metabolism theory. [72] The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible. Processes affected include pubertal growth, sebaceous gland oil production, and sexuality (especially in fetal development). Some examples of virilizing effects are growth of the clitoris in females and the penis in male children (the adult penis size does not change due to steroids [ medical citation needed] ), increased vocal cord size, increased libido, suppression of natural sex hormones, and impaired production of sperm. [137] Effects on women include deepening of the voice, facial hair growth, and possibly a decrease in breast size. Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count. [ citation needed]Prevention or treatment of osteoporosis in postmenopausal women. [18] [19] Nandrolone decanoate is approved for this use. [20] Although they have been indicated for this indication, AAS saw very little use for this purpose due to their virilizing side effects. [18] [21]

BBC News Why is steroid use rising among male bodybuilders? - BBC News

Many 19-nortestosterone derivatives, including nandrolone, trenbolone, ethylestrenol (ethylnandrol), metribolone (R-1881), trestolone, 11β-MNT, dimethandrolone, and others, are potent agonists of the progesterone receptor (PR) and hence are progestogens in addition to AAS. [72] [173] Similarly to the case of estrogenic activity, the progestogenic activity of these drugs serves to augment their antigonadotropic activity. [173] This results in increased potency and effectiveness of these AAS as antispermatogenic agents and male contraceptives (or, put in another way, increased potency and effectiveness in producing azoospermia and reversible male infertility). [173] Oral activity and hepatotoxicity [ edit ] a b Somboonporn W (2006). "Androgen and menopause". Curr. Opin. Obstet. Gynecol. 18 (4): 427–32. doi: 10.1097/01.gco.0000233938.36554.37. PMID 16794424. S2CID 8030248.Baum NH, Crespi CA (2007). "Testosterone replacement in elderly men". Geriatrics. 62 (9): 14–8. PMID 17824721. Body weight in men may increase by 2 to 5kg as a result of short-term (<10 weeks) AAS use, which may be attributed mainly to an increase of lean mass. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent. Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out. [7] Berger JR, Pall L, Hall CD, Simpson DM, Berry PS, Dudley R (1996). "Oxandrolone in AIDS-wasting myopathy". AIDS. 10 (14): 1657–62. doi: 10.1097/00002030-199612000-00010. PMID 8970686. S2CID 9832782.

Anabolic steroid misuse - NHS Anabolic steroid misuse - NHS

Copeland J, Peters R, Dillon P (March 1998). "A study of 100 anabolic-androgenic steroid users". Med. J. Aust. 168 (6): 311–2. doi: 10.5694/j.1326-5377.1998.tb140177.x. PMID 9549549. S2CID 8699231. Royal College of Physicians of London (1999). Osteoporosis: Clinical Guidelines for Prevention and Treatment. Royal College of Physicians. pp.51–. ISBN 978-1-86016-079-0. Archived from the original on 2021-04-14 . Retrieved 2017-06-25.Melmed S, et al. (2012). Williams textbook of endocrinology (12th edition). Philadelphia, PA: Saunders. Aiding weight gain following surgery or physical trauma, during chronic infection, or in the context of unexplained weight loss. [22] [23] Health risks can be produced by long-term use or excessive doses of AAS. [2] [3] These effects include harmful changes in cholesterol levels (increased low-density lipoprotein and decreased high-density lipoprotein), acne, high blood pressure, liver damage (mainly with most oral AAS), and left ventricular hypertrophy. [4] These risks are further increased when athletes take steroids alongside other drugs, causing significantly more damage to their bodies. [5] The effect of anabolic steroids on the heart can cause myocardial infarction and strokes. [5] Conditions pertaining to hormonal imbalances such as gynecomastia and testicular size reduction may also be caused by AAS. [6] In women and children, AAS can cause irreversible masculinization. [6]

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